One of the most respected neoclassical buildings on Syros Island is home to the Hermes Hotel, the largest hotel in Ermoupoli. Situated on a tiny plot of land at the right border of Syros harbour, the hotel has a superb location with the historic city core in the backdrop. With the tranquil waters of the harbor on one side and the deep blue Aegean Sea on the other, visitors are surrounded by water on all sides. The Hermes Hotel in Syros has seventy rooms that front either the sea or the bay of the port. Room amenities include air condition wifi, telephone, balcony, refrigerator, television,  bathroom with toiletries and hairdryer.

A restaurant and bar are part of the hotel amenities, serving breakfast, dinner, and beverages. The Hermes Hotel is the best option for business meetings, conferences, social gatherings, and wedding celebrations thanks to its 300 square meter ballroom hall, which offers a unique capacity of space, and its outdoor verandas with views of the sea. The Hermes hotel is a short distance from the Vaporia area and shopping center, and it is situated 200 meters from Ermoupoli's prominent town hall plaza. The airport in Syros is around 2 kilometers distant.